1,2-dehydroreticulinium reductase (NADPH)

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1,2-dehydroreticulinium reductase (NADPH)
Identifiers
EC number 1.5.1.27
CAS number 130590-58-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 1,2-dehydroreticulinium reductase (NADPH) (EC 1.5.1.27) is an enzyme that catalyzes the chemical reaction

(R)-reticuline + NADP+ 1,2-dehydroreticulinium + NADPH + H+

Thus, the two substrates of this enzyme are (R)-reticuline and NADP+, whereas its 3 products are 1,2-dehydroreticulinium, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-reticuline:NADP+ oxidoreductase. This enzyme is also called 1,2-dehydroreticulinium ion reductase. This enzyme participates in alkaloid biosynthesis i.

References[edit]

  • De-Eknamkul, Wanchai; Zenk, Meinhart H. (1992). "Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings". Phytochemistry. 31 (3): 813&ndash, 821. doi:10.1016/0031-9422(92)80020-F.