1,4-dihydroxy-2-naphthoyl-CoA hydrolase

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1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Identifiers
EC number 3.1.2.28
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

1,4-dihydroxy-2-naphthoyl-CoA hydrolase (EC 3.1.2.28) is an enzyme with systematic name 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

1,4-dihydroxy-2-naphthoyl-CoA + H2O 1,4-dihydroxy-2-naphthoate + CoA

This enzyme participates in the biosynthesis of menaquinones, phylloquinone, and several plant pigments.

References[edit]

  1. ^ Widhalm, J.R.; van Oostende, C.; Furt, F.; Basset, G.J. (2009). "A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1". Proc. Natl. Acad. Sci. USA. 106: 5599–5603. doi:10.1073/pnas.0900738106. PMC 2660889Freely accessible. PMID 19321747. 
  2. ^ Muller, W; Leistner, E (1976). "1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis". Phytochemistry. 15: 407–410. doi:10.1016/s0031-9422(00)86833-8. 
  3. ^ Eichinger D, Bacher A, Zenk MH, Eisenreich W (1999). "Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum". J. Am. Chem. Soc. 121: 7469–7475. doi:10.1021/ja990622o. 

External links[edit]