1,8-Cineole 2-exo-monooxygenase

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1,8-Cineole 2-exo-monooxygenase
Identifiers
EC number 1.14.13.157
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157, CYP3A4) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction

1,8-cineole + NADPH + H+ + O2 2-exo-hydroxy-1,8-cineole + NADP+ + H2O

1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).

References[edit]

  1. ^ Miyazawa, M.; Shindo, M.; Shimada, T. (2001). "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes". Drug Metab. Dispos. 29 (2): 200–205. PMID 11159812. 
  2. ^ Miyazawa, M.; Shindo, M. (2001). "Biotransformation of 1,8-cineole by human liver microsomes". Nat. Prod. Lett. 15 (1): 49–53. doi:10.1080/10575630108041257. PMID 11547423. 
  3. ^ Miyazawa, M.; Shindo, M.; Shimada, T. (2001). "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes". Xenobiotica. 31: 713–723. doi:10.1080/00498250110065595. PMID 11695850. 

External links[edit]