1,8-cineole synthase

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1,8-cineole synthase
EC number
CAS number 110637-19-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

1,8-cineole synthase (EC, 1,8-cineole cyclase, geranyl pyrophoshate:1,8-cineole cyclase, 1,8-cineole synthetase) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, 1,8-cineole-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

geranyl diphosphate + H2O 1,8-cineole + diphosphate

This enzyme requires Mn2+ or Zn2+.


  1. ^ Croteau, R.; Alonso, W.R.; Koepp, A.E.; Johnson, M.A. (1994). "Biosynthesis of monoterpenes: partial purification, characterization, and mechanism of action of 1,8-cineole synthase". Arch. Biochem. Biophys. 309: 184–192. doi:10.1006/abbi.1994.1101. PMID 8117108. 
  2. ^ Wise, M.L.; Savage, T.J.; Katahira, E.; Croteau, R. (1998). "Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase". J. Biol. Chem. 273: 14891–14899. doi:10.1074/jbc.273.24.14891. PMID 9614092. 
  3. ^ Peters, R.J.; Croteau, R.B. (2003). "Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases". Arch. Biochem. Biophys. 417: 203–211. doi:10.1016/s0003-9861(03)00347-3. PMID 12941302. 
  4. ^ Chen, F.; Ro, D.K.; Petri, J.; Gershenzon, J.; Bohlmann, J.; Pichersky, E.; Tholl, D. (2004). "Characterization of a root-specific Arabidopsis terpene synthase responsible for the formation of the volatile monoterpene 1,8-cineole". Plant Physiol. 135: 1956–1966. doi:10.1104/pp.104.044388. PMC 520767Freely accessible. PMID 15299125. 
  5. ^ Keszei, A.; Brubaker, C.L.; Carter, R.; Kollner, T.; Degenhardt, J.; Foley, W.J. (2010). "Functional and evolutionary relationships between terpene synthases from Australian Myrtaceae". Phytochemistry. 71: 844–852. doi:10.1016/j.phytochem.2010.03.013. PMID 20399476. 

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