2,6-dihydroxypseudooxynicotine hydrolase

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2,6-dihydroxypseudooxynicotine hydrolase
Identifiers
EC number 3.7.1.19
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2,6-dihydroxypseudooxynicotine hydrolase (EC 3.7.1.19) is an enzyme with systematic name 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase.[1][2] This enzyme catalyses the following chemical reaction

1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O 2,6-dihydroxypyridine + 4-methylaminobutanoate

The enzyme is present in the soil bacterium Arthrobacter nicotinovorans.

References[edit]

  1. ^ Gherna, R.L.; Richardson, S.H.; Rittenberg, S.C. (1965). "The bacterial oxidation of nicotine. VI, the metabolism of 2,6-dihydroxypseudooxynicotine". J. Biol. Chem. 240: 3669–3674. PMID 5835946. 
  2. ^ Sachelaru, P.; Schiltz, E.; Igloi, G.L.; Brandsch, R. (2005). "An α/β-fold C—C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans". J. Bacteriol. 187: 8516–8519. doi:10.1128/jb.187.24.8516-8519.2005. PMC 1317030Freely accessible. PMID 16321959. 

External links[edit]