N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase

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N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Identifiers
EC number 3.5.1.103
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (EC 3.5.1.103, MshB) is an enzyme with systematic name 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate

This enzyme mediates the rate limiting step in the mycothiol biosynthesis pathway.

References[edit]

  1. ^ Rawat, M.; Kovacevic, S.; Billman-Jacobe, H.; Av-Gay, Y. (2003). "Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis". Microbiology. 149: 1341–1349. doi:10.1099/mic.0.26084-0. PMID 12724395. 
  2. ^ Newton, G.L.; Av-Gay, Y.; Fahey, R.C. (2000). "N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis". J. Bacteriol. 182: 6958–6963. doi:10.1128/jb.182.24.6958-6963.2000. PMC 94821Freely accessible. PMID 11092856. 
  3. ^ Maynes, J.T.; Garen, C.; Cherney, M.M.; Newton, G.; Arad, D.; Av-Gay, Y.; Fahey, R.C.; James, M.N. (2003). "The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-α-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold". J. Biol. Chem. 278: 47166–47170. doi:10.1074/jbc.m308914200. PMID 12958317. 

External links[edit]