Phosphoribosyl-ATP diphosphatase

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phosphoribosyl-ATP diphosphatase
1yxb.jpg
phosphoribosyl-ATP pyrophosphatase tetramer, Streptomyces coelicolor
Identifiers
EC number 3.6.1.31
CAS number 69553-55-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-ATP + H2O 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides, the systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase. This enzyme participates in histidine metabolism, it employs one cofactor, H+.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1Y6X, 1YVW, 1YXB, and 2A7W.

References[edit]

  • Smith DWE; Ames BN (1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis". J. Biol. Chem. 240: 3056–3063. PMID 14342333.