6-Hydroxypseudooxynicotine dehydrogenase

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6-hydroxypseudooxynicotine dehydrogenase
Identifiers
EC number 1.5.99.14
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

6-hydroxypseudooxynicotine dehydrogenase (EC 1.5.99.14) is an enzyme with systematic name 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction

1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor

This enzyime contains a cytidylyl molybdenum cofactor.

References[edit]

  1. ^ Freudenberg, W.; Konig, K.; Andreesen, J. R. (1988). "Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase". FEMS Microbiology Letters. 52: 13–18. doi:10.1111/j.1574-6968.1988.tb02564.x. 
  2. ^ Grether-Beck, S.; Igloi, G.L.; Pust, S.; Schilz, E.; Decker, K.; Brandsch, R. (1994). "Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans". Mol. Microbiol. 13 (5): 929–936. doi:10.1111/j.1365-2958.1994.tb00484.x. PMID 7815950. 
  3. ^ Sachelaru, P.; Schiltz, E.; Brandsch, R. (2006). "A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans". Appl. Environ. Microbiol. 72 (7): 5126–5131. doi:10.1128/AEM.00437-06. PMC 1489357Freely accessible. PMID 16820521. 

External links[edit]