Cloniprazepam

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Cloniprazepam
Cloniprazepam.svg
Clinical data
Synonyms 1-Cyclopropylmethylclonazepam, Kloniprazepam, 2-Chloro-7'-nitroprazepam
Drug class Benzodiazepines
Identifiers
Chemical and physical data
Formula C19H16ClN3O3
Molar mass 369.802 g/mol
3D model (JSmol)
Metabolic pathway of cloniprazepam

Cloniprazepam is a benzodiazepine derivative and a prodrug mainly for clonazepam (a patented medicine) and other metabolites.[1], including 7-aminoclonazepam and clonazepam mentioned above (both as metabolites), which may be misinterpreted as clonazepam intake at the result of a drug test.[2]

Some of the minor metabolites include 3-hydroxy and 6-hydroxyclonazepam, 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.[2]

It is a designer drug and an NPS (short for "new psychoactive substance").[1] At the end of 2017, cloniprazepam remains an uncontrolled substance in most of the countries.

See Also[edit]

References[edit]

  1. ^ a b Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (November 2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080–1089. doi:10.1002/jms.3840. PMID 27535017. 
  2. ^ a b Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; M. Huppertz, Laura; Auwärter, Volker (2016-08-01). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam: Update on designer benzodiazepines". Journal of Mass Spectrometry. 51. doi:10.1002/jms.3840. 

External Links[edit]