DXP reductoisomerase

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1-deoxy-D-xylulose-5-phosphate reductoisomerase
PDB 1q0q EBI.jpg
crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose 5-phosphate
Identifiers
Symbol DXP_reductoisom
Pfam PF02670
Pfam clan CL0063
InterPro IPR013512
SCOP 1onn
SUPERFAMILY 1onn
DXP reductoisomerase
Identifiers
EC number 1.1.1.267
CAS number 210756-42-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

DXP reductoisomerase (1-deoxy-D-xylulose 5-phosphate reductoisomerase or DXR) is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).[1]

It is classified under EC 1.1.1.267. It is normally abbreviated DXR, but it is sometimes named IspC, as the product of the ispC gene.

DXR is part of the MEP pathway (nonmevalonate pathway) of isoprenoid precursor biosynthesis. DXR can be is inhibited by fosmidomycin.

This enzyme is required for terpenoid biosynthesis in some organisms, since it is a key enzyme on the MEP pathway for the production of the isoprenoid precursors IPP and DMAPP.[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the MEP pathway for isoprenoid precursor biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.

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This article incorporates text from the public domain Pfam and InterPro IPR013512 This article incorporates text from the public domain Pfam and InterPro IPR013644