1-Deoxypentalenic acid 11beta-hydroxylase

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1-deoxypentalenic acid 11beta-hydroxylase
Identifiers
EC number 1.14.11.35
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

1-deoxypentalenic acid 11beta-hydroxylase (EC 1.14.11.35, PTLH (gene), SAV2991 (gene), PNTH (gene)) is an enzyme with systematic name 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

1-deoxypentalenate + 2-oxoglutarate + O2 1-deoxy-11beta-hydroxypentalenate + succinate + CO2

1-Deoxypentalenic acid 11beta-hydroxylase contains Fe(II) and ascorbate.

References[edit]

  1. ^ You, Z.; Omura, S.; Ikeda, H.; Cane, D.E. (2006). "Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis". J. Am. Chem. Soc. 128 (20): 6566–6567. doi:10.1021/ja061469i. PMC 2533727Freely accessible. PMID 16704250. 
  2. ^ You, Z.; Omura, S.; Ikeda, H.; Cane, D.E.; Jogl, G. (2007). "Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis". J. Biol. Chem. 282 (50): 36552–36560. doi:10.1074/jbc.M706358200. PMC 3010413Freely accessible. PMID 17942405. 

External links[edit]