Glycerophospholipid acyltransferase (CoA-dependent)

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glycerophospholipid acyltransferase (CoA-dependent)
Identifiers
EC number 2.3.1.148
CAS number 9054-54-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a glycerophospholipid acyltransferase (CoA-dependent) (EC 2.3.1.148) is an enzyme that catalyzes the chemical reaction

1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are 1-organyl-2-acyl-sn-glycero-3-phosphocholine and 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine, whereas its two products are 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine and 1-organyl-2-lyso-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-gly cero-3-phosphoethanolamine acyltransferase (CoA-dependent).

References[edit]

  • Irvine RF, Dawson RM (1979). "Transfer of arachidonic acid between phospholipids in rat liver microsomes". Biochem. Biophys. Res. Commun. 91 (4): 1399–405. doi:10.1016/0006-291X(79)91222-1. PMID 526311. 
  • Robinson M, Blank ML, Snyder F (1985). "Acylation of lysophospholipids by rabbit alveolar macrophages Specificities of CoA-dependent and CoA-independent reactions". J. Biol. Chem. 260 (13): 7889–95. PMID 4008481. 
  • Snyder F, Lee TC, Blank ML (1992). "The role of transacylases in the metabolism of arachidonate and platelet activating factor". Prog. Lipid. Res. 31 (1): 65–86. doi:10.1016/0163-7827(92)90016-C. PMID 1641397.