Queen bee acid

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Queen bee acid
Queen Bee Acid.svg
Names
IUPAC name
(E)-10-Hydroxydec-2-enoic acid
Other names
10-Hydroxy-2-decenoic acid
Royal Jelly acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.236.030
MeSH C055543
Properties
C10H18O3
Molar mass 186.25 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

The queen bee acid (10-hydroxy-2-decenoic acid) or 10-HDA is a bio-active compound found in royal jelly.[1][2][3][4]

Royal jelly acid is being investigated for its pharmacological activities. Reports indicate that it promotes neurogenesis of neural stem/progenitor cells (cells capable of differentiating into neurons, astrocytes, or oligodendrocytes) in vitro and could provide an effective method to treat and prevent neurological disorders.[5]

In addition, royal jelly acid has been reported to have anti-tumor, anti-biotic, immunomodulatory, estrogenic, neurogenic, and innate immune response modulating activities.[6]

See also[edit]

Notes[edit]

References[edit]

  1. ^ Bian, M. T. [Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography]. Chung Yao Tung Pao. 12(6):41-43, 1987.
  2. ^ Bloodworth, BC; Harn, CS; Hock, CT; Boon, YO (Jul–Aug 1995). "Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly" (PDF). Journal of AOAC International. 78 (4): 1019–23. PMID 7580313. 
  3. ^ Genç, Mahmut; Aslan, Abdurrahman. "Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography". Journal of Chromatography A. 839 (1-2): 265–268. doi:10.1016/S0021-9673(99)00151-X. PMID 10327631. 
  4. ^ Ji, N; Yu, RG; Yang, QH; Yu, PH; Li, Y (Jul 1987). "[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography]". Zhong yao tong bao (Beijing, China : 1981). 12 (9): 28–31, 62. PMID 3449246. 
  5. ^ Hattori, Noriko; Nomoto, Hiroshi; Fukumitsu, Hidefumi; Mishima, Satoshi; Furukawa, Shoei (2007-01-01). "Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro". Biomedical Research. 28 (5): 261–266. doi:10.2220/biomedres.28.261. 
  6. ^ "Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses". doi:10.2174/187153012803832530#sthash.lrbba94a.dpuf.