Vellosimine dehydrogenase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
vellosimine dehydrogenase
Identifiers
EC number 1.1.1.273
CAS number 86777-26-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a vellosimine dehydrogenase (EC 1.1.1.273) is an enzyme that catalyzes the chemical reaction

10-deoxysarpagine + NADP+ vellosimine + NADPH + H+

Thus, the two substrates of this enzyme are 10-deoxysarpagine and NADP+, whereas its 3 products are vellosimine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-deoxysarpagine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

References[edit]

  • Pfitzner A, Krausch B, Stockigt J (1984). "Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine". Tetrahedron. 40 (10): 1691–1699. doi:10.1016/S0040-4020(01)91118-4.