Linoleate 10R-lipoxygenase

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Linoleate 10R-lipoxygenase
Identifiers
EC number 1.13.11.62
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Linoleate 10R-lipoxygenase (EC 1.13.11.62, 10R-DOX, (10R)-dioxygenase, 10R-dioxygenase) is an enzyme with systematic name linoleate:oxygen (10R)-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

linoleate + O2 (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate

Linoleate 10R-lipoxygenase is involved in biosynthesis of oxylipins.

References[edit]

  1. ^ Garscha, U.; Oliw, E.H. (2009). "Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity". J. Biol. Chem. 284 (20): 13755–13765. doi:10.1074/jbc.M808665200. PMC 2679477Freely accessible. PMID 19289462. 
  2. ^ Jerneren, F.; Garscha, U.; Hoffmann, I.; Hamberg, M.; Oliw, E.H. (2010). "Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus". Biochim. Biophys. Acta. 1801 (4): 503–507. doi:10.1016/j.bbalip.2009.12.012. PMID 20045744. 

External links[edit]