Leandro Bueno Bergantin is a PhD from the Universidade Federal de São Paulo and the primary author of a paper on the discovery of the "calcium paradox" in sympathetic transmission. Dr. Bergantin received his academic education at EPM-UNIFESP and UAM: degree in biomedicine, MSc and PhD, his research involves cell signaling mediated by Ca2+ and cAMP, skeletal and smooth muscles and central nervous systems. His research work solved the enigma of the paradoxical effects produced by L-type Ca2+ channel blockers. Since 1975, several clinical and experimental studies have reported that acute and chronic administration of L-type voltage-activated Ca2+ channels blockers, such as nifedipine, produces reduction in arterial pressure associated with an increase of sympathetic activity. Despite this sympathetic hyperactivity has been attributed to adjust reflex of arterial pressure, the cellular and molecular mechanisms involved in this apparent sympathomimetic effect of the L-type VACCs blockers remained unclear for decades.
In 2013, Dr. Bergantin and collaborators discovered that this paradoxical increase in sympathetic activity produced by L-type VACCs blockers is due to interaction of the Ca2+/cAMP signaling pathways; the pharmacological manipulation of the Ca2+/cAMP interaction produced by combination of the L-type VACCs blockers used in the antihypertensive therapy, cAMP accumulating compounds used in the antidepressive therapy, could represent a potential cardiovascular risk for hypertensive patients due to increase in sympathetic activity. In contrast, this pharmacological manipulation could be a new therapeutic strategy for increasing neurotransmission in psychiatric disorders, producing neuroprotection in the neurodegenerative diseases; the original article was listed as a "hot article" in ScienceDirect. Http://academicbridges.blogspot.com.es/2014/01/up-to-thousand-words_20.html
The 1971 Sandlapper 200 was a NASCAR Winston Cup Series racing event that took place on August 27, 1971, at Columbia Speedway in Columbia, South Carolina. The race car drivers still had to commute to the races using the same stock cars that competed in a typical weekend's race through a policy of homologation; this policy was in effect until 1975. By 1980, NASCAR had stopped tracking the year model of all the vehicles and most teams did not take stock cars to the track under their own power anymore. Columbia Speedway was an oval racetrack located in a suburb of Columbia, South Carolina, it was the site of auto races for NASCAR's top series from 1951 through 1971. For most of its history, the racing surface was dirt; the races in April and August 1970 were two of the final three Grand National races held on a dirt track. The track was paved before hosting its last two Grand National races in 1971. While Columbia Speedway was shut down to cars in 1979, noise complaints, it reopened as a velodrome in 2001.
Two hundred laps were completed on a paved oval track spanning 0.500 miles in only one hour and thirty-four minutes. Six cautions were given for forty-one laps. Local track announcer Jim Seay would realize the charismatic potential of Petty and interviewed him right after the race in front of a regional crowd. Eight thousand people showed up in person to see cars achieve speeds of up to 64.831 miles per hour. Richard Petty, would achieve the pole position speed of 85.137 miles per hour. Ron Keselowski would crash prior to the first lap of the race; the combined winnings purse for this race would be $9,275. H. B. Bailey was running in second place. Last top-10 finish for Ken Meisenhelder; the Massachusetts driver had three top-10 finishes in all of them finishing 10th. Lee Gordon, Vic Ballard and Dale Inman were among the three most notable crew chiefs to participate in this event. Inman was in charge of keeping Richard Petty's car in good order while Vic Ballard looked after Walter Ballard. Lee Gordon's primary responsibility was keeping Cecil Gordon's vehicle in decent working order.
Section reference: Richard Petty, official time 1:34:24 Tiny Lund, 10 car lengths down Jim Paschal, finished lead lap under green flag James Hylton, 3 laps down Jabe Thomas, 4 laps down Wayne Andrews, 4 laps down Elmo Langley, 6 laps down Walter Ballard, 7 laps down Randy Hutchison, 7 laps down Ken Meisenhelder, 10 laps down Section reference: Start of race: Richard Petty had the pole position to start out the event. Lap 2: H. B. Bailey took over the lead from Richard Petty. Lap 11: The ignition on Marv Acton's vehicle stopped working properly. Lap 13: Richard Petty took over the lead from H. B. Bailey. Lap 17: Richard Childress' vehicle managed to overheat itself. Lap 21: Earl Brooks' vehicle managed to overheat itself. Lap 52: Jim Paschal took over the lead from Richard Petty. Lap 55: H. B. Bailey had a terminal crash. Lap 67: Richard Petty took over the lead from Jim Paschal. Lap 68: The brakes on D. K. Ulrich's vehicle stopped working properly. Lap 109: Issues with the vehicle's clutch took Ernie Shaw out of the race.
Lap 124: Tiny Lund took over the lead from Richard Petty. Lap 143: Ed Negre had ignition problems that forced him out of the event. Lap 152: Frank Warren couldn't steer his vehicle properly, forcing him to leave for safety reasons. Lap 159: J. D. McDuffie had a terminal crash. Lap 162: Jimmy Vaughn had a terminal crash. Lap 188: Richard Petty took over the lead from Tiny Lund. Finish: Richard Petty was declared the winner of the event