The 10th Annual Latin Grammy Awards took place on Thursday, November 5, 2009, at the Mandalay Bay Events Center in Las Vegas, Nevada. This was the second time the show took place in Las Vegas. Juan Gabriel was honored as the Latin Recording Academy Person of the Year on November 4, the day prior to the telecast. Calle 13 were the big winners, winning five awards including Album of the Year. 2009 marked the tenth anniversary of the Latin Grammy Awards.

The Michelob Ultra Arena, formerly the Mandalay Bay Events Center, is a 12,000-seat multi-purpose indoor arena at the Mandalay Bay Resort and Casino, located on the Las Vegas Strip in Paradise, Nevada. It is owned and operated by MGM Resorts International, and was opened on April 10, 1999. MGM and brewing company Anheuser-Busch entered a naming-rights agreement in 2021, naming the arena after the company's Michelob Ultra beer.