11-cis-retinol dehydrogenase

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11-cis-retinol dehydrogenase
EC number
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ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

11-cis-retinol dehydrogenase (EC, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

11-cis-retinol---[retinal-binding-protein] + NAD+ 11-cis-retinal---[retinol-binding-protein] + NADH + H+

This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.


  1. ^ Simon, A.; Hellman, U.; Wernstedt, C.; Eriksson, U. (1995). "The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". J. Biol. Chem. 270: 1107–1112. doi:10.1074/jbc.270.3.1107. PMID 7836368. 
  2. ^ Wang, J.; Chai, X.; Eriksson, U.; Napoli, J.L. (1999). "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue". Biochem. J. 338: 23–27. doi:10.1042/0264-6021:3380023. PMC 1220019Freely accessible. PMID 9931293. 
  3. ^ Liden, M.; Romert, A.; Tryggvason, K.; Persson, B.; Eriksson, U. (2001). "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus". J. Biol. Chem. 276 (52): 49251–49257. doi:10.1074/jbc.M107337200. PMID 11675386. 
  4. ^ Wu, Z.; Yang, Y.; Shaw, N.; Bhattacharya, S.; Yan, L.; West, K.; Roth, K.; Noy, N.; Qin, J.; Crabb, J.W. (2003). "Mapping the ligand binding pocket in the cellular retinaldehyde binding protein". J. Biol. Chem. 278: 12390–12396. doi:10.1074/jbc.M212775200. PMID 12536149. 

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