11-cis-retinyl-palmitate hydrolase

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11-cis-retinyl-palmitate hydrolase
Identifiers
EC number 3.1.1.63
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 11-cis-retinyl-palmitate hydrolase (EC 3.1.1.63) is an enzyme that catalyzes the chemical reaction

11-cis-retinyl palmitate + H2O 11-cis-retinol + palmitate

Thus, the two substrates of this enzyme are 11-cis-retinyl palmitate and H2O, whereas its two products are 11-cis-retinol and palmitate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds, the systematic name of this enzyme class is 11-cis-retinyl-palmitate acylhydrolase. Other names in common use include 11-cis-retinol palmitate esterase, and RPH. This enzyme participates in retinol metabolism, this enzyme has at least one effector, Bile salt.

References[edit]

  • Blaner WS, Das SR, Gouras P, Flood MT (1987). "Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells". J. Biol. Chem. 262 (1): 53–8. PMID 3793734. 
  • Blaner WS, Prystowsky JH, Smith JE, Goodman DS (1984). "Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities". Biochim. Biophys. Acta. 794 (3): 419–27. doi:10.1016/0005-2760(84)90008-0. PMID 6743673.