11-cis-retinyl-palmitate hydrolase

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11-cis-retinyl-palmitate hydrolase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 11-cis-retinyl-palmitate hydrolase (EC is an enzyme that catalyzes the chemical reaction

11-cis-retinyl palmitate + H2O 11-cis-retinol + palmitate

Thus, the two substrates of this enzyme are 11-cis-retinyl palmitate and H2O, whereas its two products are 11-cis-retinol and palmitate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds, the systematic name of this enzyme class is 11-cis-retinyl-palmitate acylhydrolase. Other names in common use include 11-cis-retinol palmitate esterase, and RPH. This enzyme participates in retinol metabolism, this enzyme has at least one effector, Bile salt.


  • Blaner WS, Das SR, Gouras P, Flood MT (1987). "Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells". J. Biol. Chem. 262 (1): 53–8. PMID 3793734. 
  • Blaner WS, Prystowsky JH, Smith JE, Goodman DS (1984). "Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities". Biochim. Biophys. Acta. 794 (3): 419–27. doi:10.1016/0005-2760(84)90008-0. PMID 6743673.