15-Cis-phytoene desaturase

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15-cis-phytoene desaturase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

15-Cis-phytoene desaturase (EC, phytoene desaturase (ambiguous), PDS, plant-type phytoene desaturase) is an enzyme with systematic name 15-cis-phytoene:plastoquinone oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 2 plastoquinone 9,15,9'-tricis-zeta-carotene + 2 plastoquinol (overall reaction)
(1a) 15-cis-phytoene + plastoquinone 15,9'-dicis-phytofluene + plastoquinol
(1b) 15,9'-dicis-phytofluene + plastoquinone 9,15,9'-tricis-zeta-carotene + plastoquinol

This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria.


  1. ^ Breitenbach, J.; Zhu, C.; Sandmann, G. (2001). "Bleaching herbicide norflurazon inhibits phytoene desaturase by competition with the cofactors". J. Agric. Food Chem. 49 (11): 5270–5272. doi:10.1021/jf0106751. PMID 11714315.
  2. ^ Schneider, C.; Boger, P.; Sandmann, G. (1997). "Phytoene desaturase: heterologous expression in an active state, purification, and biochemical properties". Protein Expr. Purif. 10 (2): 175–179. doi:10.1006/prep.1997.0730. PMID 9226712.
  3. ^ Fraser, P.D.; Linden, H.; Sandmann, G. (1993). "Purification and reactivation of recombinant Synechococcus phytoene desaturase from an overexpressing strain of Escherichia coli". Biochem. J. 291: 687–692. PMC 1132422. PMID 8489496.
  4. ^ Breitenbach, J.; Sandmann, G. (2005). "ζ-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene". Planta. 220: 785–793. doi:10.1007/s00425-004-1395-2. PMID 15503129.

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