1503 in science
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- May 10 – Christopher Columbus first sights the Cayman Islands, which he names Las Tortugas after the numerous sea turtles there.
- April 21 – Battle of Cerignola: Spanish forces defeat the French, considered the first battle in history won by gunpowder small arms.
- Giuliano da Sangallo constructs the city waIls of Arezzo in Tuscany using the new technology of bastions.