1504 in science
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- probable date – Pedro Reinel's Atlantic chart is the earliest known nautical chart with a scale of latitudes, and with a wind rose having a clear fleur-de-lys.
- February 29 – Christopher Columbus uses his knowledge of a lunar eclipse this night to convince Jamaican tribesmen to provide him with supplies.
- November 7 – Columbus returns to Spain from his fourth and last voyage, in which he and his younger son, Ferdinand, explored the coast of Central America from Belize to Panama.
- exact date unknown – Domenico Maria Novara da Ferrara (born 1554), Italian astronomer.