1515 in science
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- A year in which Earth's so-called "second moon" Cruithne (discovered in 1986) makes a closest approach to earth. The two are in 1:1 orbital resonance. This next happens about 1903; the following occasion will be in July 2292.
- May 15 – An Indian rhinoceros arrives in Lisbon, the first to be seen in Europe since Roman times.
- February 18 – Valerius Cordus, German physician and botanist (died 1544)
- Cristóbal Acosta, Portuguese physician and natural historian (died 1594)
- Giorgio Biandrata, Italian court physician (died 1588)
- Petrus Ramus, French logician (k. 1572)
- Johann Weyer, Dutch physician and occultist (died 1588)
- approx. date – Leonard Digges, English mathematician and surveyor (d. c.1559)
- Alonso de Ojeda, Spanish navigator (born c.1466)
- Andreas Stoberl, Austrian astronomer, mathematician and theologian (born 1465)