The 1570 Ferrara earthquake struck the Italian city of Ferrara on November 16 and 17, 1570. After the initial shocks, a sequence of aftershocks continued for four years, with over 2,000 in the period from November 1570 to February 1571.

Ferrara is a city and comune (municipality) in Emilia-Romagna, Northern Italy, capital of the province of Ferrara. As of 2016, it had 132,009 inhabitants. It is situated 44 kilometres northeast of Bologna, on the Po di Volano, a branch channel of the main stream of the Po River, located 5 km north. The town has broad streets and numerous palaces dating from the Renaissance, when it hosted the court of the House of Este. For its beauty and cultural importance, it has been designated by UNESCO as a World Heritage Site.