16β,17α-Epiestriol

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16β,17α-Epiestriol
16β,17α-Epiestriol.svg
Names
IUPAC name
(8R,9S,13S,14S,16S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
Identifiers
3D model (JSmol)
ChemSpider
Properties
C18H24O3
Molar mass 288.39 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

16β,17α-Epiestriol, or 16,17-epiestriol, also known as 16β-hydroxy-17α-estradiol, as well as estra-1,3,5(10)-triene-3,16β,17α-triol, is a minor and weak endogenous steroidal estrogen that is related to 17α-estradiol and estriol.[1][2] Along with estriol, 16β,17α-epiestriol has been detected in the urine of women during the late pregnancy stage.[2] It shows preferential affinity for the ERβ over the ERα.[3]

See also[edit]

References[edit]

  1. ^ Vitamins and Hormones. Academic Press. 18 April 1972. pp. 233–. ISBN 978-0-08-086626-0. 
  2. ^ a b Ryō Satō; Ryūichi Katō (1982). Microsomes, drug oxidations, and drug toxicity. Japan Scientific Societies Press. p. 273. ISBN 978-0-471-87285-6. 
  3. ^ Zhu BT, Han GZ, Shim JY, Wen Y, Jiang XR (2006). "Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding". Endocrinology. 147 (9): 4132–50. doi:10.1210/en.2006-0113. PMID 16728493.