16-alpha-hydroxysteroid dehydrogenase

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16-alpha-hydroxysteroid dehydrogenase
Identifiers
EC number 1.1.1.147
CAS number 37250-74-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

a 16alpha-hydroxysteroid + NAD(P)+ a 16-oxosteroid + NAD(P)H + H+

The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD+, and NADP+, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.

References[edit]

  • Meigs RA, Ryan KJ (1966). "16-alpha-hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties". J. Biol. Chem. 241 (17): 4011–5. PMID 4380686.