1622 in science
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- The slide rule is invented by William Oughtred (1574–1660), an English mathematician, and later becomes the calculating tool of choice until the electronic calculator takes over in the early 1970s.
Physiology and medicine
- Gaspare Aselli discovers the lacteal vessels of the lymphatic system.
- Flemish anatomist Giulio Casserio publishes Nova anatomia in Frankfurt, containing clear copperplate engravings of the human anatomy.
- February 22 – An English patent is granted for Dud Dudley's process for smelting iron ore with coke.
- January 28 – Adrien Auzout, French astronomer (died 1691)
- March 10 – Johann Rahn, Swiss mathematician (died 1676)
- April 5 – Vincenzo Viviani, Italian mathematician and scientist (died 1703)
- undated – Jean Pecquet, French anatomist, discoverer of the thoracic duct (died 1674)
- January 23 – William Baffin, English explorer and navigator (born 1584)
- February 19 – Sir Henry Savile, English polymath and benefactor (born 1549)
- April 13 – Katharina Kepler, German healer and mother of Johannes Kepler (born 1546)
- May 15 – Petrus Plancius, Flemish cartographer and cosmographer (born 1552)
- "Oughtred Society Slide Rule History". The Oughtred Society. 2007-09-15. Archived from the original on 21 December 2007. Retrieved 2007-12-29.
- De lactibus sive Lacteis venis. Milan. 1627.
- Premuda, Loris (1970). "Aselli, Gaspare". Dictionary of Scientific Biography. 1. New York: Charles Scribner's Sons. pp. 315–316. ISBN 0-684-10114-9.