1630 in science
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- Francesco Stelluti's Persio tradotto in verso schiolto e dichiarato, published in Rome, is the first book to contain images of organisms viewed through the microscope.
- The first laws prohibiting gambling in America are passed.
- September 13 – Olof Rudbeck, Swedish physiologist (died 1702)
- October – Isaac Barrow, English mathematician (died 1677)
- possible date – Johann Kunckel, German chemist (died 1703)
- November 15 – Johannes Kepler, astronomer (born 1571)
- Federico Cesi, founder of Accademia Nazionale dei Lincei, in Rome, Italy (born 1586)
- Johannes Schreck (also known as Johannes Terrenz or Terrentius), explorer (born 1576)
- Norman, Jeremy. "The First Book to Contain Images of Organisms Viewed through the Microscope (1630)". History of Knowledge. Retrieved 2014-12-02.
- Richardson, Matthew (2001). The Penguin Book of Firsts. New Delhi: Penguin Books India. ISBN 0-14-302771-9.