1646 in science
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- Pascal's Law, a law of hydrostatics is developed, stating that, in a perfect fluid, the pressure exerted on it anywhere is transmitted equally.
- Dr Thomas Browne's Pseudodoxia Epidemica is published in London, introducing the words electricity, medical, pathology, hallucination and computer to the English language and casting doubt on the theory of spontaneous generation.
- April 20 – Charles Plumier, French botanist (died 1704)
- July 1 – Gottfried Leibniz, German scientist and mathematician (died 1716)