1648 in science
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- September 19 – Blaise Pascal's brother-in-law, Florin Périer, demonstrates in an ascent of the Puy-de-Dôme that atmospheric pressure varies with height.
- Jan Baptist van Helmont's collected works, Ortus medicinae, vel opera et opuscula omnia, are published posthumously by Lodewijk Elzevir in Amsterdam, edited and Latinized by his son Franciscus Mercurius van Helmont. Transitional between alchemy and chemistry, it contains the results of numerous experiments and establishes an early version of the law of conservation of mass.
- September 1 – Marin Mersenne, French mathematician (born 1588)
- November 3 – John Bainbridge, English astronomer (born 1582)
- Jacqueline Bergeron, ed. (2013). Highlights of Astronomy: As Presented at the XXIst General Assembly of the IAU, 1991. Springer Science & Business Media. p. 521. ISBN 9401128286.
- Fisher, Raymond H., ed. (1981). The Voyage of Semen Dezhnev in 1648. London: Hakluyt Society. ISBN 0-904180-07-7.
- Erickson, Robert F. "Willem Piso". Rare Books from the MBG Library. Missouri Botanical Garden. Retrieved 2011-04-02.
- "Johann Baptista van Helmont". History of Gas Chemistry. Center for Microscale Gas Chemistry, Creighton University. 2005-09-25. Retrieved 2007-02-23.