1658 in science
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- Jan Swammerdam observes red blood cells (in the frog) with the aid of a microscope.
- Samuel Volckertzoon observes a quokka on Rottnest Island.
- March 5 – Antoine Laumet de La Mothe, sieur de Cadillac, French explorer (died 1730)
- April 2 - Pierre Pomet, French pharmacist (died 1699)
- unknown date – Nicolas Andry, French physician (died 1742)