16S rRNA (adenine1408-N1)-methyltransferase

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16S rRNA (adenine1408-N1)-methyltransferase
EC number
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ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

16S rRNA (adenine1408-N1)-methyltransferase (EC, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine1408 in 16S rRNA S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA

The enzyme provides a panaminoglycoside resistance through interference with the binding of aminoglycosides.


  1. ^ Beauclerk, A.A.; Cundliffe, E. (1987). "Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides". J. Mol. Biol. 193: 661–671. doi:10.1016/0022-2836(87)90349-4. PMID 2441068. 
  2. ^ Koscinski, L.; Feder, M.; Bujnicki, J.M. (2007). "Identification of a missing sequence and functionally important residues of 16S rRNA:m1A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics". Cell Cycle. 6: 1268–1271. doi:10.4161/cc.6.10.4231. PMID 17495534. 
  3. ^ Holmes, D.J.; Drocourt, D.; Tiraby, G.; Cundliffe, E. (1991). "Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius". Gene. 102: 19–26. doi:10.1016/0378-1119(91)90532-g. PMID 1840536. 
  4. ^ Wachino, J.; Shibayama, K.; Kurokawa, H.; Kimura, K.; Yamane, K.; Suzuki, S.; Shibata, N.; Ike, Y.; Arakawa, Y. (2007). "Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides". Antimicrob. Agents Chemother. 51: 4401–4409. doi:10.1128/aac.00926-07. PMC 2168023Freely accessible. PMID 17875999. 

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