16S rRNA (cytidine1409-2'-O)-methyltransferase

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16S rRNA (cytidine1409-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.227
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

16S rRNA (cytidine1409-2'-O)-methyltransferase (EC 2.1.1.227, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine1409 in 16S rRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA

The bifunctional enzyme from Mycobacterium tuberculosis.

References[edit]

  1. ^ Johansen, S.K.; Maus, C.E.; Plikaytis, B.B.; Douthwaite, S. (2006). "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs". Mol. Cell. 23: 173–182. doi:10.1016/j.molcel.2006.05.044. PMID 16857584. 
  2. ^ Maus, C.E.; Plikaytis, B.B.; Shinnick, T.M. (2005). "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis". Antimicrob. Agents Chemother. 49 (2): 571–577. doi:10.1128/AAC.49.2.571-577.2005. PMC 547314Freely accessible. PMID 15673735. 

External links[edit]