16S rRNA (guanine1207-N2)-methyltransferase

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16S rRNA (guanine1207-N2)-methyltransferase
Identifiers
EC number 2.1.1.172
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

16S rRNA (guanine1207-N2)-methyltransferase (EC 2.1.1.172, m2G1207 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine1207 in 16S rRNA S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA

The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA.

References[edit]

  1. ^ Tscherne, J.S.; Nurse, K.; Popienick, P.; Ofengand, J. (1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli". J. Biol. Chem. 274: 924–929. doi:10.1074/jbc.274.2.924. PMID 9873033. 
  2. ^ Sunita, S.; Purta, E.; Durawa, M.; Tkaczuk, K.L.; Swaathi, J.; Bujnicki, J.M.; Sivaraman, J. (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC". Nucleic Acids Res. 35: 4264–4274. doi:10.1093/nar/gkm411. PMC 1934991Freely accessible. PMID 17576679. 

External links[edit]