16S rRNA (guanine527-N7)-methyltransferase

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16S rRNA (guanine527-N7)-methyltransferase
Identifiers
EC number 2.1.1.170
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

16S rRNA (guanine527-N7)-methyltransferase (EC 2.1.1.170, ribosomal RNA small subunit methyltransferase G, 16S rRNA methyltransferase RsmG, GidB, rsmG (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine527-N7)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine527 in 16S rRNA S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA

The enzyme specifically methylates guanine527 at N7 in 16S rRNA.

References[edit]

  1. ^ Okamoto S, Tamaru A, Nakajima C, Nishimura K, Tanaka Y, Tokuyama S, Suzuki Y, Ochi K (February 2007). "Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria". Molecular Microbiology. 63 (4): 1096–106. doi:10.1111/j.1365-2958.2006.05585.x. PMID 17238915. 
  2. ^ Romanowski MJ, Bonanno JB, Burley SK (June 2002). "Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold". Proteins. 47 (4): 563–7. doi:10.1002/prot.10121. PMID 12001236. 

External links[edit]