16S rRNA pseudouridine516 synthase

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16S rRNA pseudouridine516 synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

16S rRNA pseudouridine516 synthase (EC, 16S RNA pseudouridine516 synthase, 16S PsiI516 synthase, 16S RNA Psi516 synthase, RNA pseudouridine synthase RsuA, RsuA, 16S RNA pseudouridine 516 synthase) is an enzyme with systematic name 16S rRNA-uridine516 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction

16S rRNA uridine516 16S rRNA pseudouridine516

The enzyme is specific for uridine516 in 16S rRNA.


  1. ^ Wrzesinski J, Bakin A, Nurse K, Lane BG, Ofengand J (July 1995). "Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli". Biochemistry. 34 (27): 8904–13. doi:10.1021/bi00027a043. PMID 7612632.
  2. ^ Conrad J, Niu L, Rudd K, Lane BG, Ofengand J (June 1999). "16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases". Rna. 5 (6): 751–63. doi:10.1017/s1355838299990167. PMC 1369802. PMID 10376875.
  3. ^ Sivaraman J, Sauvé V, Larocque R, Stura EA, Schrag JD, Cygler M, Matte A (May 2002). "Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP". Nature Structural Biology. 9 (5): 353–8. doi:10.1038/nsb788. PMID 11953756.

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