17-alpha-hydroxyprogesterone aldolase

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17α-Hydroxyprogesterone aldolase
Identifiers
EC number 4.1.2.30
CAS number 62213-24-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 17α-hydroxyprogesterone aldolase (EC 4.1.2.30) is an enzyme that catalyzes the chemical reaction

17α-hydroxyprogesterone androst-4-en-3,17-dione + acetaldehyde

Hence, this enzyme has one substrate, 17α-hydroxyprogesterone, and two products, androst-4-en-3,17-dione and acetaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds, the systematic name of this enzyme class is 17α-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming). Other names in common use include C-17/C-20-lyase, and 17α-hydroxyprogesterone acetaldehyde-lyase. This enzyme participates in androgen and estrogen metabolism.

References[edit]

  • Nowotny E, Sananez RD, Nattero G, Yantorno C, Faillaci MG (1974). "Bioconversion of steroids in vitro by testes from autoimmunized rabbits". Hoppe-Seyler's Z. Physiol. Chem. 355 (6): 716–20. doi:10.1515/bchm2.1974.355.1.716. PMID 4435747.