1768 in music
- Johann Christian Bach gives the first ever solo piano performance, in London on an instrument by Johannes Zumpe.
- Wolfgang Amadeus Mozart and his family are resident in Vienna until December.
- Antonio Sacchini returns to Venice to become director of the Conservatorio dell'Ospadeletto.
- Giuseppe Tartini suffers a stroke.
- Michael Haydn marries Maria Magdalena Lipp, a singer and the daughter of the court organist.
- "The Liberty Song", with words by John Dickinson – considered the first American patriotic song. He used the music to the traditional British song, Hearts of Oak.
- Wolfgang Amadeus Mozart – Bastien und Bastienne (his first published opera)
- Joseph Haydn – Lo speziale
- Niccolò Jommelli – Fetonte
- Giovanni Paisiello – Olimpia
- Antonio Zingarelli – I quattro pazzi
- Applausus – Joseph Haydn
- Symphonies No. 7 and No. 8 – Wolfgang Amadeus Mozart
- Cello Concerto in D Major – Luigi Boccherini
- Sonata for Harpsichord in G major – Muzio Clementi
- Six Sonatas for the Harpsichord, piano forte and organ with accompanyments for two violins and a violoncello, Op. 2 – John Garth
- March 12 – Carolus Antonius Fodor, composer
- April 7 – Karl Theodor Toeschi, composer
- September 1 – Carl Bernhard Wessely, composer
- September 12 – Benjamin Carr, composer
- September 14 – Georg Johann Schinn, composer
- September 21 – Louis-Emmanuel Jadin, composer, pianist and harpsichordist (c. 1863)
- November 24 – Jean-Engelbert Pauwels, composer
- December 6 – Johann Baptist Henneberg, composer
- date unknown – Gaetano Crivelli, operatic tenor (d. 1836)
- January 1 – Jean-Laurent Krafft, composer
- January 28 – John Wainwright, composer
- March 3 – Nicola Porpora, composer
- March 14 – Vigilio Blasio Faitello, composer
- July 6 – Johann Conrad Beissel, composer
- July 11 – José Melchior de Nebra Blascu, composer
- October 28 – Michel Blavet, flautist and composer
- October 31 – Francesco Maria Veracini, violinist and composer
- November 1 – Pierre van Maldere, composer