1769 in music
- Luigi Boccherini goes to Madrid as the court chamber music composer to the Infante Don Luis.
- Wenzel Pichl becomes musical director for Count Ludwig Hartig in Prague
- 14-year-old Mozart hears Allegri's Miserere for the first time, returns home and copies it down note for note.
- Charles Burney receives an honorary doctorate in music from the University of Oxford.
- Antonio Maria Gaspare Sacchini arrives in Venice.
- James Hook is appointed composer to Marylebone Gardens.
- Jean-François Cailhava – Les Etrenes de l'amour
- Christoph Willibald von Gluck – Le feste d'Apollo
- André Grétry – Lucile
- Pierre-Alexandre Monsigny – Le déserteur
- Wolfgang Amadeus Mozart – La finta semplice
- Josef Mysliveček – Demofoonte
- Johann Albrechtsberger – Concerto for Trombone in B flat major
- Carl Philipp Emmanuel Bach – Die Israeliten in der Wüste (oratorio)
- François Joseph Gossec – Sei quartetti per flauto e violino o sia per due violini, alto e basso, op. 14
- Wolfgang Amadeus Mozart – Te Deum in C
- Johann Baptist Wanhal – Quartet for Strings in B flat major, Op. 2 no 3
- January 2 – Nannette Streicher, German piano maker, composer, music educator and writer (died 1833)
- March 7 – Josef Alois Ladurner, Austrian composer and music educator (died 1851)
- March 8 – Katerina Veronika Anna Dusíkova, Bohemian singer, harpist, pianist and composer (died 1833)
- March 25 – Salvatore Viganò, choreographer, dancer and composer (died 1821)
- June 5 – Marianne Kirchgessner, German musician (d. 1808)
- April 11 – Johann Georg Lickl, organist and composer (died 1843)
- April 25 – Charles Borremans, violinist and conductor (died 1827)
- June 1 – Józef Elsner, composer and music teacher, Chopin's future teacher (died 1854)
- July 4 – Louis-Luc Loiseau de Persuis, violinist, conductor and composer (died 1819)
- July 23 – Alexey Nikolayevich Titov, violinist and composer (died 1827)
- August 14 – Friedrich Dülon, flautist (died 1826)
- September 12 – Reginald Spofforth, organist, conductor and composer (died 1827)
- Date unknown – Charles Hague, composer (died 1821)