Tankyrase known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase-1 is a poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.
Stimulates 26S proteasome activity. TNKS has been shown to interact with
Will Cherry is an American professional basketball player for Pallacanestro Reggiana of Lega Basket Serie A. He played college basketball for the University of Montana, where he was named Big Sky Conference Defensive Player of the Year in 2012 and 2013. Cherry had a short stint in the NBA with the Cleveland Cavaliers before playing in Lithuania, Germany and Croatia. Cherry attended McClymonds High School in California; as a senior, he averaged 12.0 points, 8.0 rebounds, 5.0 assists, a league-leading 4.0 steals per game for the undefeated Warriors, going on to be named league and team MVP. In 116 career collegiate games for the Montana Grizzlies, Cherry averaged 12.8 points on.430 shooting with 3.6 rebounds, 3.4 assists, 2.3 steals in 30.7 minutes per game. He was named first team All-Big Sky Conference three times, was the Big Sky Defensive Player of the year in 2011–12 and 2012–13, is seventh on the school's all-time scoring list with 1,484 points. After going undrafted in the 2013 NBA draft, Cherry joined the New Orleans Pelicans for the 2013 NBA Summer League.
On February 13, 2014, he was acquired by the Canton Charge of the NBA Development League. In July 2014, Cherry joined the Cleveland Cavaliers for the 2014 NBA Summer League. On August 3, 2014, he signed with the Toronto Raptors. However, he was waived by the Raptors on October 25, 2014. On November 2, 2014, Cherry was reacquired by the Canton Charge; that day, he signed with the Cleveland Cavaliers. On November 30, 2014, he was waived by the Cavaliers after appearing in eight games and averaging 1.9 points and 1 assist per game. On December 7, 2014, Cherry signed with Žalgiris Kaunas of Lithuania for the rest of the season. On June 6, 2015, he helped. In July 2015, Cherry joined the San Antonio Spurs for the 2015 NBA Summer League. On September 1, 2015, he signed with Alba Berlin of Germany for the 2015–16 season. With Alba, he won the German Cup in 2016. In August 2016, Cherry signed with Gaziantep Basketbol of the Turkish Basketball Super League. On July 29, 2017, Cherry signed with Croatian team Cedevita Zagreb for the 2017–18 season.
On October 8, 2018, Cherry signed with the Golden State Warriors. He was waived three days later, he was added to the Santa Cruz Warriors. In 46 games played for the Warriors, he averaged 4.2 assist and 1.6 steals per game. On April 13, 2019, Cherry signed with Olympiacos of the Greek Basket League for the rest of the season. On July 23, 2019, Cherry signed a one-year contract extension with Olympiacos. On January 15, 2020, Cherry and Olympiacos parted ways, he signed with Pallacanestro Reggiana of Lega Basket Serie A on January 26. Note: The EuroLeague is not the only competition in which the player participated for the team during the season, he played in domestic competition, regional competition if applicable. Cherry is the son of Yvette Martin, has a younger brother, Marsean. On April 27, 2013, Cherry was arrested for disorderly conduct and resisting arrest after he was involved in a fight in front of Stockman's Bar in Missoula, Montana. Career statistics and player information from Basketball-Reference.com Will Cherry at euroleague.net Will Cherry at nbadleague.com Montana Grizzlies bio Will Cherry on Twitter
Kent County is a county located in the U. S. state of Texas. As of the 2010 census, its population was 808, its county seat is Jayton. The county was created in 1876 and organized in 1892, it is named for Andrew Kent. Kent County is one of six prohibition or dry counties in the state of Texas. Republican Drew Springer, Jr. a businessman from Muenster in Cooke County, has since January 2013 represented Kent County in the Texas House of Representatives. 8000 BC Paleo-Indians were the first inhabitants. Native American inhabitants included the Wanderers band of Comanche. 1872 Ranald S. Mackenzie and his soldiers trounced the Comanches at Treasure Butte, southeast of Clairemont. 1876 The Texas legislature formed Kent County from Bexar districts. The new county is named after Alamo defender Andrew Kent. 1888 Cattleman R. L. Rhomberg settled in the new county and named a settlement Clairemont for his daughter, Claire. 1890 The county census recorded 324 residents. 1891 A conflict arose between cattle ranchers and farmers who tried to fence their farms against cattle.
1892 Kent County was organized, with Clairemont as the county seat. 1900 The county population was 899. 1909 The Stamford and Northeastern Railway built a line across the county's northeast corner. The railroad, which connected Stamford and Spur became part of the Wichita Valley Railroad; the Jayton community was founded. 1930 The county's population peaked at 3,851. 1946-1991 Oil was discovered in Kent County in 1946. By 1991, more than 448,448,000 barrels of oil have been produced in the county since 1946. According to the U. S. Census Bureau, the county has a total area of 903 square miles, of which 903 square miles are land and 0.4 square miles is covered by water. U. S. Highway 380 State Highway 70 State Highway 208 Dickens County Stonewall County Fisher County Scurry County Garza County King County Crosby County As of the census of 2000, 859 people, 353 households, 247 families resided in the county; the population density was less than 1/km². The 551 housing units averaged about 0.6 1 per square mile.
The racial makeup of the county was 95.46% White, 0.23% Black or African American, 0.35% Native American, 3.73% from other races, 0.23% from two or more races. About 9 % of the population were Latino of any race. Of the 353 households, 26.10% had children under the age of 18 living with them, 61.20% were married couples living together, 5.90% had a female householder with no husband present, 30.00% were not families. About 28% of all households were made up of individuals, 14.20% had someone living alone, 65 years of age or older. The average household size was 2.33 and the average family size was 2.83. In the county, the population was distributed as 20.60% under the age of 18, 5.40% from 18 to 24, 21.80% from 25 to 44, 26.80% from 45 to 64, 25.50% who were 65 years of age or older. The median age was 47 years. For every 100 females, there were 91.70 males. For every 100 females age 18 and over, there were 91.60 males. The median income for a household in the county was $30,433, for a family was $35,568.
Males had a median income of $23,875 versus $20,000 for females. The per capita income for the county was $17,626. About 9.20% of families and 10.40% of the population were below the poverty line, including 13.10% of those under age 18 and 6.10% of those age 65 or over. Jayton Girard Clairemont Dry counties Double Mountain Fork Brazos River National Register of Historic Places listings in Kent County, Texas Recorded Texas Historic Landmarks in Kent County Kent County government’s website Kent County from the Handbook of Texas Online Kent County Profile from the Texas Association of Counties
Chanel was a female dachshund, from the United States, that held the Guinness World Records as the world's oldest dog. She died at the age of 21 on August 28, 2009. Chanel was only 6 weeks old when Mrs. Shaughnessy, a single mother at the time, adopted her from a shelter while serving with the United States Army in Newport News, Virginia, in 1988. Along with her owner, Chanel spent six years in Germany. In her years, she wore tinted goggles for her cataracts, was transported in a stroller because she could no longer walk for long distances without difficulty and favored sweaters because she was sensitive to the cold. Chanel died from natural causes on August 28, 2009, at her home in Port Jefferson Station, New York, at the age of 21. Chanel was cremated after her death, it was mistakenly reported by Sky News that Chanel had died in January 2010, they had in fact mixed her up with the dog, recognized by Guinness World Records as the oldest dog after her death, Otto. This caused other news websites to repeat the error, including Shortnews.com.
Chanel was nominated for the title of world's oldest dog by the Shaughnessy family after noticing the Guinness World Records had no entry. The previous holder, had died in 2003. Shaughnessy forwarded written records verifying Chanel's age to the Guinness organization noting that families residing on American military bases must keep documents on their pets. Shaughnessy explained. You keep records."Guinness World Records officials presented Chanel with a certificate as the world's oldest dog at a Manhattan birthday bash hosted by a private pet-food company in May 2009. Chanel became a minor celebrity in the United States following her 2009 certification as the world's oldest dog, she appeared Live! With Regis and Kelly and the Today Show and the Kathy Lee Show. Chanel and her owner attended several fundraisers, including at New York's Tavern on the Green, though Chanel attended them in a stroller since she could no longer walk for long distances on her own. Gabbatt, Adam. "Chanel, the world's oldest dog, dies at 21".
Ranby is a small village in the north of Nottinghamshire, next to the Chesterfield Canal and adjacent to the A1. It is in the civil parish of Babworth, it is known for its two schools, the prep school Worksop College Preparatory School and the primary school Ranby Primary School, the nearby church All Saints Babworth. Ranby Prison is located on the A620 to Retford; the Prison houses an increasing number of inmates. Nearby stood Morton Hall, built for William Mason J. P. in the 1860s. His children included Harriet Mason and Arthur James Mason; the hall was demolished in 1946. The grounds of the hall contained a "Money Stone"; the one metre high stone commemorates a hoard found in 1802 containing 621 Roman copper and silver coins. The 1802 stone is now listed. Agnes Mason, founded the Community of the Holy Family Arthur James Mason, theologian, was the son of G. W. Mason, of Morton Hall Harriet Mason, Poor Law Inspector Media related to Ranby at Wikimedia Commons