18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase

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18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase (EC, 18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA

DIM1 is involved in pre-rRNA processing.


  1. ^ Lafontaine, D.; Vandenhaute, J.; Tollervey, D. (1995). "The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast". Genes Dev. 9: 2470–2481. doi:10.1101/gad.9.20.2470. PMID 7590228. 
  2. ^ Lafontaine, D.L.; Preiss, T.; Tollervey, D. (1998). "Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis". Mol. Cell. Biol. 18: 2360–2370. doi:10.1128/mcb.18.4.2360. PMC 121492Freely accessible. PMID 9528805. 
  3. ^ Pulicherla, N.; Pogorzala, L.A.; Xu, Z.; O'Farrell, H.C.; Musayev, F.N.; Scarsdale, J.N.; Sia, E.A.; Culver, G.M.; Rife, J.P. (2009). "Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases". J. Mol. Biol. 391: 884–893. doi:10.1016/j.jmb.2009.06.015. PMC 2753216Freely accessible. PMID 19520088. 
  4. ^ Lafontaine, D.; Delcour, J.; Glasser, A.L.; Desgres, J.; Vandenhaute, J. (1994). "The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast". J. Mol. Biol. 241: 492–497. doi:10.1006/jmbi.1994.1525. PMID 8064863. 
  5. ^ O'Farrell, H.C.; Pulicherla, N.; Desai, P.M.; Rife, J.P. (2006). "Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution". RNA. 12: 725–733. doi:10.1261/rna.2310406. PMC 1440906Freely accessible. PMID 16540698. 

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