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2,2-Dimethoxypropane Structural Formula V1.svg
2,2-dimethoxypropane ball view
IUPAC name
Other names
acetone dimethyl acetal
3D model (JSmol)
ECHA InfoCard 100.000.961
EC Number 201-056-0
Molar mass 104.15 g/mol
Appearance Colorless liquid
Density 0.85 g/cm3
Melting point −47 °C (−53 °F; 226 K)
Boiling point 83 °C (181 °F; 356 K)
15 g/L (20 °C)
Safety data sheet External MSDS
GHS pictograms GHS02: FlammableGHS07: Harmful
GHS signal word Danger
H225, H315, H319, H335
P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+352, P303+361+353, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P370+378, P403+233, P403+235, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

2,2-Dimethoxypropane (DMP) is an organic compound with the formula (CH3)2C(OCH3)2. A colorless liquid, it is the product of the reaction of acetone and methanol, according to the equation below:[2]


DMP is commonly used as a water scavenger in water-sensitive reactions. Upon acid-catalyzed reaction, DMP reacts quantitatively with water to form acetone and methanol;[3] this property can be used to accurately determine the amount of water in a sample, alternatively to Karl Fischer method.[4]

DMP is specifically used to prepare acetonides:[5][6]


Dimethoxypropane is an intermediate for the synthesis of 2-methoxypropene.

In histology, DMP is used for the dehydration of animal tissue.[7]


  1. ^ 2,2-Dimethoxypropane at Sigma-Aldrich
  2. ^ CN103772167A, 顾金林, "Preparation method of 2, 2-dimethoxypropane", published 1981-02-26, assigned to 浙江胡涂硅有限公司 
  3. ^ Critchfield, F. E., Bishop, E. T. (1961). "Water determination by reaction with 2, 2-dimethoxypropane". Anal. Chem. 33: 1034. doi:10.1021/ac60176a051.CS1 maint: Uses authors parameter (link)
  4. ^ Martin, J. H., Knevel, A. M. (1965). "Gas chromatographic method of moisture determination". J. Pharm. Sci. 54: 1464. doi:10.1002/jps.2600541013.CS1 maint: Uses authors parameter (link)
  5. ^ Christopher R. Schmid, Jerry D. Bryant (1995). "D-(R)-Glyceraldehyde Acetonide". Org. Synth. 72: 6. doi:10.15227/orgsyn.072.0006.CS1 maint: Uses authors parameter (link)
  6. ^ Christian Hubschwerlen, Jean-luc Specklin, J. Higelin (1995). "L-(S)-glyceraldehyde Acetonide". Org. Synth. 72: 1. doi:10.15227/orgsyn.072.0001.CS1 maint: Uses authors parameter (link)
  7. ^ Poul Prentø (1978). "Rapid dehydration--clearing with 2,2-dimethoxypropane for paraffin embedding". J. Histochem. Cytochem. 26: 865. doi:10.1177/26.10.363931.CS1 maint: Uses authors parameter (link)

External links[edit]