2,6-dihydroxypseudooxynicotine hydrolase

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2,6-dihydroxypseudooxynicotine hydrolase
Identifiers
EC number3.7.1.19
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

2,6-dihydroxypseudooxynicotine hydrolase (EC 3.7.1.19) is an enzyme with systematic name 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase.[1][2] This enzyme catalyses the following chemical reaction

1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O 2,6-dihydroxypyridine + 4-methylaminobutanoate

The enzyme is present in the soil bacterium Arthrobacter nicotinovorans.

References[edit]

  1. ^ Gherna, R.L.; Richardson, S.H.; Rittenberg, S.C. (1965). "The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine". J. Biol. Chem. 240: 3669–3674. PMID 5835946.
  2. ^ Sachelaru, P.; Schiltz, E.; Igloi, G.L.; Brandsch, R. (2005). "An α/β-fold C—C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans". J. Bacteriol. 187: 8516–8519. doi:10.1128/jb.187.24.8516-8519.2005. PMC 1317030. PMID 16321959.

External links[edit]