Dimethoxybromoamphetamine known as brolamfetamine and bromo-DMA, is a psychedelic drug and substituted amphetamine of the phenethylamine class of compounds. DOB was first synthesized by Alexander Shulgin in 1967, its synthesis and effects are documented in Shulgin's book PiHKAL: A Chemical Love Story. The full name of the chemical is 2,5-dimethoxy-4-bromoamphetamine. DOB has a stereocenter and R--DOB is the eutomer; this is an important finding as it is suggestive that it is targeting different receptors relative to most other phenethylamines where the R-isomer serves as the distomer. The toxicity of DOB is not known, although high doses may cause serious vasoconstriction of the extremities. DOB is one of the most potent compounds in PiHKAL. Omission of the amphetamine related α-methyl leads to 2C-B, a compound that possesses a lower affinity for the 5-HT2A receptor and is a weaker receptor agonist which results in drastically reduced vasoconstriction. DOB is a 5-HT2A, 5-HT2B, 5-HT2C receptor partial agonist.
Its psychedelic effects are mediated by its agonistic properties at the 5-HT2A receptor. Due to its selectivity, DOB is used in scientific research when studying the 5-HT2 receptor subfamily, it is an agonist of human TAAR1. It has been suggested. Excessively high doses of this hallucinogen may cause diffuse arterial spasm; the vasospasm responded to intra-arterial and intravenous vasodilators, such as tolazoline. Internationally DOB is a Schedule I drug under the Convention on Psychotropic Substances. Listed as a Schedule 1 as it is an analogue of amphetamine. DOB is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard. A Schedule 9 substance is a substance which may be abused or misused, the manufacture, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities. Schedule I, possession of at least 10mg is a criminal offence.
William Spencer was an early settler of Western Australia. Arriving in Bunbury from England in 1842, he remained in the area for the rest of his life, serving several terms as the town's mayor, he was elected to the colony's Legislative Council of Western Australia in 1896, serving until his death. Spencer was born in Bath, England, to Margaret and Thomas Henry Spencer, his mother was a granddaughter of a rear admiral in the Royal Navy. At the age of 17, Spencer stowed away to Australia on the Trusty, arriving in Bunbury in December 1842. On arrival, he was employed as a shepherd, but had his wages docked to pay off his passage. Spencer worked as a police constable, a court clerk, a tidewaiter, he became involved in the construction trade, as a contractor helped to build the Bunbury Timber Jetty, the Wellington Hotel, St Paul's Church. A long-serving member of the Bunbury Municipal Council, Spencer served as mayor of Bunbury on four occasions, from 1872 to 1875, from 1877 to 1879, in 1881, from 1891 to 1893.
He was a chairman of the Wellington Road Board. At the 1896 Legislative Council elections, Spencer was elected to South-West Province, replacing the retiring John Foulkes. Aged 71, he became the oldest MP in Western Australia to be elected for the first time. Only two others have since been elected for the first time at an older age. Spencer died in Bunbury in July 1901, aged 76, he had married Hannah Properjohn in March 1855. He was widowed in December 1898, remarried in March 1901, to Mary Ann Oakley. One of his daughters by his first wife married James Mitchell, a future state premier
On February 26, 2015, a gunman shot and killed seven people in several locations across the town of Tyrone, Missouri, an unincorporated community 95 miles east of Springfield. The gunman, identified as 36-year-old Joseph Jesse Aldridge, was found dead of a self-inflicted gunshot wound the next day, it was the worst mass murder in the history of Texas County, which had experienced an average of one homicide per year. Police were alerted to the shootings at 10:15 p.m. CT Thursday, when a 15-year-old girl ran to a neighbor's home to say she heard gunshots in her home and fled. Deputies responded and found her parents and Julie Aldridge, dead inside the home. A few miles away, officers found Garold's brother Harold and his wife Janell shot to death inside their bedroom; as a result, police began checking all of the houses in Tyrone, urging citizens to stay inside their residences and lock their doors. Less than three miles away and Martha Shriver were both shot in their home. While Darrell died from his wounds, Martha survived and managed to identify the suspect as Joseph Jesse Aldridge as she was being taken to a hospital in Springfield.
She had a relative check on the well-being of her son Carey and his family. The relative found Carey and his wife Valirea dead on the floor of their bedroom, their son sleeping unharmed in another bedroom; the entire shooting spree occurred within a three-mile radius of Tyrone. All of the crime scenes showed no signs of forced entry into the homes. An elderly woman connected to the shootings died from natural causes. Authorities believe the gunman started the shooting spree after finding his mother, the aforementioned elderly woman, dead on a couch from an illness for which she had been under a doctor's care, though this was unconfirmed; the disease was clarified in an autopsy to be metastatic lung cancer, although according to the woman's brother, it was breast cancer. A relative feared the woman did not die from the disease, had instead been smothered to death by Aldridge; the woman was identified as 74-year-old Alice L. Aldridge. At around 5:30 a.m. on February 27, the gunman was found dead inside a pickup truck situated in the middle of a two-lane highway.
He was southeast of Summersville in neighboring Shannon County, located about fifteen or twenty miles away from the scenes of the shootings. He died of a self-inflicted gunshot wound earlier that day. A Rock Island Armory 1911.45-caliber handgun, believed to be the same one used in the shootings, was recovered from the truck along with a stash of ammunition. The shootings were the worst mass murder in the history of Texas County, which had an average of one homicide per year. Joseph Jesse Aldridge was identified as the gunman in the shootings, he was a cousin of the named male victims. On June 15, 2007, Aldridge was arrested in Howell County for felony marijuana possession, during which he was found to have a Ruger 22/45.22-caliber pistol in his possession. On May 2, 2008, he was sentenced to 21 months in a federal prison for owning the pistol, he was released three years though a judge added six months of his arrest to his sentence in 2011 at the request of Aldridge's probation officer. He was ordered to undergo mental health and substance abuse counseling.
Aldridge was known to local law enforcement. His record at the time of the shooting barred him from owning guns. Aldridge was described as a recluse by relatives. Arkansas Democrat-Gazette reported that he was involved in a feud with a cousin, one of the victims in the shootings, that Aldridge and several other members of his extended family were having tense relations between one another following a fistfight involving Aldridge's brother; the Aldridge family was said to have had a feud with the Shriver family that lasted for years. According to a relative of the Shriver family and other residents of Tyrone, Aldridge had asked Darrell Shriver, one of the slain victims and a neighbor of his, for a job at a cabinet store he owned prior to the shootings, but was turned down, he had reportedly threatened to kill other residents. All of the victims in the shooting were adults, in total, they made up around 10 percent of the town's entire population. In the hours after the shootings, four of the seven casualties were identified by police, while the others were identified by relatives and friends before being confirmed by police.
They are: Missouri Governor Jay Nixon made a statement on the shootings, saying, "This is a horrific tragedy, our hearts go out to the victims of these senseless acts and their families." He added. Houston Mayor Don Tottingham said, "This is a terrible tragedy in a community that's real close-knit; this is a great town, this is why it's such a tragedy because it shows you're vulnerable to things."