2-Amino-4-deoxychorismate synthase

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2-amino-4-deoxychorismate synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-amino-4-deoxychorismate synthase (EC, ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(2S)-2-amino-4-deoxychorismate + L-glutamate chorismate + L-glutamine

This enzyme requires Mg2+. The reaction occurs in the reverse direction.


  1. ^ Van Lanen, S.G.; Lin, S.; Shen, B. (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proc. Natl. Acad. Sci. USA. 105 (2): 494–499. doi:10.1073/pnas.0708750105. PMC 2206564. PMID 18182490.
  2. ^ Yu, L.; Mah, S.; Otani, T.; Dedon, P. (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117: 8877–8878. doi:10.1021/ja00139a032.
  3. ^ McDonald, M.; Mavrodi, D.V.; Thomashow, L.S.; Floss, H.G. (2001). "Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid". J. Am. Chem. Soc. 123: 9459–9460. doi:10.1021/ja011243. PMID 11562236.
  4. ^ Laursen, J.B.; Nielsen, J. (2004). "Phenazine natural products: biosynthesis, synthetic analogues, and biological activity". Chem. Rev. 104 (3): 1663–1686. doi:10.1021/cr020473j. PMID 15008629.

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