2-dehydropantolactone reductase (A-specific)

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
2-dehydropantolactone reductase (A-specific)
EC number
CAS number 37211-75-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2-dehydropantolactone reductase (A-specific) (EC is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP+ 2-dehydropantolactone + NADPH + H+

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP+, whereas its 3 products are 2-dehydropantolactone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP+ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).


  • King HL Jr, Dyar RE, Wilken DR (Aug 10, 1974). "Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 249 (15): 4689–4695. PMID 4603075. 
  • Wilken DR, King HL Jr, Dyar RE (March 25, 1975). "Ketopantoic acid and ketopantoyl lactone reductases: Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate". J. Biol. Chem. 250 (6): 2311–2314. PMID 234966.