2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

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2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction:

  1. (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + succinate
  2. (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + fumarate

This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation.


  1. ^ Burlingame, R.; Chapman, P.J. (1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155 (1): 113–121. PMC 217659Freely accessible. PMID 6345502. 
  2. ^ Burlingame, R.P.; Wyman, L.; Chapman, P.J. (1986). "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". J. Bacteriol. 168 (1): 55–64. PMC 213419Freely accessible. PMID 3531186. 
  3. ^ Lam, W. W. Y; Bugg, T. D. H. (1994). "Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage". J. Chem. Soc., Chem. Commun. 10 (10): 1163–1164. doi:10.1039/c39940001163. 
  4. ^ Lam, W.W.; Bugg, T.D. (1997). "Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase". Biochemistry. 36 (40): 12242–12251. doi:10.1021/bi971115r. PMID 9315862. 
  5. ^ Ferrández, A.; García, J.L.; Díaz, E. (1997). "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". J. Bacteriol. 179 (8): 2573–2581. PMC 179006Freely accessible. PMID 9098055. 
  6. ^ Díaz, E.; Ferrández, A.; García, J.L. (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–2923. PMC 107259Freely accessible. PMID 9603882. 

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