2-oxo-acid reductase

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2-oxo-acid reductase
EC number1.1.99.30
CAS number115299-99-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

In enzymology, a 2-oxo-acid reductase (EC is an enzyme that catalyzes the chemical reaction

a (2R)-hydroxy-carboxylate + acceptor a 2-oxo-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are (2R)-hydroxy-carboxylate and acceptor, whereas its two products are 2-oxo-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (2R)-hydroxy-carboxylate:acceptor oxidoreductase. Other names in common use include (2R)-hydroxycarboxylate-viologen-oxidoreductase, HVOR, and 2-oxoacid reductase.


  • Trautwein T, Krauss F, Lottspeich F, Simon H (1994). "The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein". Eur. J. Biochem. 222 (3): 1025&ndash, 32. doi:10.1111/j.1432-1033.1994.tb18954.x. PMID 8026480.
  • Neumann S, Simon H (1985). "On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species". FEBS Lett. 167 (1): 29&ndash, 32. doi:10.1016/0014-5793(84)80826-1.