Purdue University is a public research university in West Lafayette and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette businessman John Purdue donated land and money to establish a college of science and agriculture in his name; the first classes were held on September 1874, with six instructors and 39 students. The main campus in West Lafayette offers more than 200 majors for undergraduates, over 69 masters and doctoral programs, professional degrees in pharmacy and veterinary medicine. In addition, Purdue has more than 900 student organizations. Purdue is a member of the Big Ten Conference and enrolls the second largest student body of any university in Indiana, as well as the fourth largest foreign student population of any university in the United States. In 1865, the Indiana General Assembly voted to take advantage of the Morrill Land-Grant Colleges Act of 1862, began plans to establish an institution with a focus on agriculture and engineering.
Communities throughout the state offered their facilities and money to bid for the location of the new college. Popular proposals included the addition of an agriculture department at Indiana State University or at what is now Butler University. By 1869, Tippecanoe County’s offer included $150,000 from Lafayette business leader and philanthropist John Purdue, $50,000 from the county, 100 acres of land from local residents. On May 6, 1869, the General Assembly established the institution in Tippecanoe County as Purdue University, in the name of the principal benefactor. Classes began at Purdue on September 1874, with six instructors and 39 students. Professor John S. Hougham was Purdue’s first faculty member and served as acting president between the administrations of presidents Shortridge and White. A campus of five buildings was completed by the end of 1874. Purdue issued its first degree, a Bachelor of Science in chemistry, in 1875 and admitted its first female students that fall. Emerson E. White, the university’s president from 1876 to 1883, followed a strict interpretation of the Morrill Act.
Rather than emulate the classical universities, White believed Purdue should be an "industrial college" and devote its resources toward providing a liberal education with an emphasis on science and agriculture. He intended not only to prepare students for industrial work, but to prepare them to be good citizens and family members. Part of White's plan to distinguish Purdue from classical universities included a controversial attempt to ban fraternities; this ban was overturned by the Indiana Supreme Court and led to White's resignation. The next president, James H. Smart, is remembered for his call in 1894 to rebuild the original Heavilon Hall "one brick higher" after it had been destroyed by a fire. By the end of the nineteenth century, the university was organized into schools of agriculture and pharmacy, former U. S. President Benjamin Harrison was serving on the board of trustees. Purdue's engineering laboratories included testing facilities for a locomotive and a Corliss steam engine, one of the most efficient engines of the time.
The School of Agriculture was sharing its research with farmers throughout the state with its cooperative extension services and would undergo a period of growth over the following two decades. Programs in education and home economics were soon established, as well as a short-lived school of medicine. By 1925 Purdue had the largest undergraduate engineering enrollment in the country, a status it would keep for half a century. President Edward C. Elliott oversaw a campus building program between the world wars. Inventor and trustee David E. Ross coordinated several fundraisers, donated lands to the university, was instrumental in establishing the Purdue Research Foundation. Ross's gifts and fundraisers supported such projects as Ross–Ade Stadium, the Memorial Union, a civil engineering surveying camp, Purdue University Airport. Purdue Airport was the country's first university-owned airport and the site of the country's first college-credit flight training courses. Amelia Earhart joined the Purdue faculty in 1935 as a consultant for these flight courses and as a counselor on women's careers.
In 1937, the Purdue Research Foundation provided the funds for the Lockheed Electra 10-E Earhart flew on her attempted round-the-world flight. Every school and department at the university was involved in some type of military research or training during World War II. During a project on radar receivers, Purdue physicists discovered properties of germanium that led to the making of the first transistor; the Army and the Navy conducted training programs at Purdue and more than 17,500 students and alumni served in the armed forces. Purdue set up about a hundred centers throughout Indiana to train skilled workers for defense industries; as veterans returned to the university under the G. I. Bill, first-year classes were taught at some of these sites to alleviate the demand for campus space. Four of these sites are now degree-granting regional campuses of the Purdue University system. Purdue's on-campus housing became racially desegregated in 1947, following pressure from Purdue President Frederick L. Hovde and Indiana Governor Ralph F. Gates.
After the war, Hovde worked to expand the academic opportunities at the university. A decade-long construction program emphasized research. In the late 1950s and early 1960s the university established programs in veterinary medicine, industrial management, nursing, as well as the first computer science department in the United States. Undergraduate humanities courses were strengthened
Simplified molecular-input line-entry system
The simplified molecular-input line-entry system is a specification in the form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules; the original SMILES specification was initiated in the 1980s. It has since been extended. In 2007, an open standard called. Other linear notations include the Wiswesser line notation, ROSDAL, SYBYL Line Notation; the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. Acknowledged for their parts in the early development were "Gilman Veith and Rose Russo and Albert Leo and Corwin Hansch for supporting the work, Arthur Weininger and Jeremy Scofield for assistance in programming the system." The Environmental Protection Agency funded the initial project to develop SMILES. It has since been modified and extended by others, most notably by Daylight Chemical Information Systems.
In 2007, an open standard called "OpenSMILES" was developed by the Blue Obelisk open-source chemistry community. Other'linear' notations include the Wiswesser Line Notation, ROSDAL and SLN. In July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is considered to have the advantage of being more human-readable than InChI; the term SMILES refers to a line notation for encoding molecular structures and specific instances should be called SMILES strings. However, the term SMILES is commonly used to refer to both a single SMILES string and a number of SMILES strings; the terms "canonical" and "isomeric" can lead to some confusion when applied to SMILES. The terms are not mutually exclusive. A number of valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol. Algorithms have been developed to generate the same SMILES string for a given molecule; this SMILES is unique for each structure, although dependent on the canonicalization algorithm used to generate it, is termed the canonical SMILES.
These algorithms first convert the SMILES to an internal representation of the molecular structure. Various algorithms for generating canonical SMILES have been developed and include those by Daylight Chemical Information Systems, OpenEye Scientific Software, MEDIT, Chemical Computing Group, MolSoft LLC, the Chemistry Development Kit. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database; the original paper that described the CANGEN algorithm claimed to generate unique SMILES strings for graphs representing molecules, but the algorithm fails for a number of simple cases and cannot be considered a correct method for representing a graph canonically. There is no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, double bond geometry; these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES.
A notable feature of these rules is. The term isomeric SMILES is applied to SMILES in which isotopes are specified. In terms of a graph-based computational procedure, SMILES is a string obtained by printing the symbol nodes encountered in a depth-first tree traversal of a chemical graph; the chemical graph is first trimmed to remove hydrogen atoms and cycles are broken to turn it into a spanning tree. Where cycles have been broken, numeric suffix labels are included to indicate the connected nodes. Parentheses are used to indicate points of branching on the tree; the resultant SMILES form depends on the choices: of the bonds chosen to break cycles, of the starting atom used for the depth-first traversal, of the order in which branches are listed when encountered. Atoms are represented by the standard abbreviation of the chemical elements, in square brackets, such as for gold. Brackets may be omitted in the common case of atoms which: are in the "organic subset" of B, C, N, O, P, S, F, Cl, Br, or I, have no formal charge, have the number of hydrogens attached implied by the SMILES valence model, are the normal isotopes, are not chiral centers.
All other elements must be enclosed in brackets, have charges and hydrogens shown explicitly. For instance, the SMILES for water may be written as either O or. Hydrogen may be written as a separate atom; when brackets are used, the symbol H is added if the atom in brackets is bonded to one or more hydrogen, followed by the number of hydrogen atoms if greater than 1 by the sign + for a positive charge or by - for a negative charge. For example, for ammonium. If there is more than one charge, it is written as digit.
The Jmol applet, among other abilities, offers an alternative to the Chime plug-in, no longer under active development. While Jmol has many features that Chime lacks, it does not claim to reproduce all Chime functions, most notably, the Sculpt mode. Chime requires plug-in installation and Internet Explorer 6.0 or Firefox 2.0 on Microsoft Windows, or Netscape Communicator 4.8 on Mac OS 9. Jmol operates on a wide variety of platforms. For example, Jmol is functional in Mozilla Firefox, Internet Explorer, Google Chrome, Safari. Chemistry Development Kit Comparison of software for molecular mechanics modeling Jmol extension for MediaWiki List of molecular graphics systems Molecular graphics Molecule editor Proteopedia PyMOL SAMSON Official website Wiki with listings of websites and moodles Willighagen, Egon. "Fast and Scriptable Molecular Graphics in Web Browsers without Java3D". Doi:10.1038/npre.2007.50.1
A hallucinogen is a psychoactive agent which can cause hallucinations, perceptual anomalies, other substantial subjective changes in thoughts and consciousness. The common types of hallucinogens are psychedelics and deliriants. Although hallucinations are a common symptom of amphetamine psychosis, amphetamines are not considered hallucinogens, as they are not a primary effect of the drugs themselves. While hallucinations can occur when abusing stimulants, the nature of stimulant psychosis is not unlike delirium. A debate persists on criteria which would differentiate a substance which is'psychedelic' from one'hallucinogenic'. Sir Thomas Browne in 1646 coined the term'hallucination' from the Latin word "alucinari" meaning "to wander in the mind"; the term'psychedelic' is derived from the Ancient Greek words psychē and dēloun, or "mind-revealing".'A hallucinogen' and'a psychedelic' may refer to the same substance.'Hallucinations' and'psychedelia' may both refer to the same aspects of subjective experience in a given instance.
The term psychedelia carries an added reference to psychedelic substance culture, and'psychedelics' are considered by many to be the'traditional' or'classical hallucinogens' including DMT, Psilocybin, LSD.'A hallucinogen' in this sense broadly refers to any substance which causes changes in perception or hallucinations, while psychedelics carry a positive connotation of general perceptual enhancement. In contrast to Hollister's original criteria, adverse effects may predominate with some hallucinogens with this application of the term; the word psychedelic was coined to express the idea of a drug that makes manifest a hidden but real aspect of the mind. It is applied to any drug with perception-altering effects such as LSD and other ergotamine derivatives, DMT and other tryptamines including the alkaloids of Psilocybe spp. mescaline and other phenethylamines. The term "psychedelic" is applied somewhat interchangeably with "psychotomimetic" and "hallucinogen", The classical hallucinogens are considered to be the representative psychedelics and LSD is considered the prototypical psychedelic.
In order to refer to the LSD-like psychedelics, scientific authors have used the term "classical hallucinogen" in the sense defined by Glennon: "The classical hallucinogens are agents that meet Hollister's original definition, but are agents that: bind at 5-HT2 serotonin receptors, are recognized by animals trained to discriminate 1--2-aminopropane from vehicle. Otherwise, when the term "psychedelic" is used to refer only to the LSD-like psychedelics, authors explicitly point that they intend "psychedelic" to be understood according to this more restrictive interpretation. One explanatory model for the experiences provoked by psychedelics is the "reducing valve" concept, first articulated in Aldous Huxley's book The Doors of Perception. In this view, the drugs disable the brain's "filtering" ability to selectively prevent certain perceptions, emotions and thoughts from reaching the conscious mind; this effect has been described as mind expanding, or consciousness expanding, for the drug "expands" the realm of experience available to conscious awareness.
While possessing a unique mechanism of action, cannabis or marijuana has been regarded alongside the classic psychedelics. A designer drug is a structural or functional analog of a controlled substance, designed to mimic the pharmacological effects of the original drug while at the same time avoid being classified as illegal and/or avoid detection in standard drug tests. Many designer drugs and research chemicals are hallucinogenic in nature, such as those in the 2C and 25-NB families. Dissociatives produce analgesia and catalepsy at anesthetic doses, they produce a sense of detachment from the surrounding environment, hence "the state has been designated as dissociative anesthesia since the patient seems disassociated from his environment." Dissociative symptoms include the disruption or compartmentalization of "...the integrated functions of consciousness, identity or perception."p. 523 Dissociation of sensory input can cause derealization, the perception of the outside world as being dream-like or unreal.
Other dissociative experiences include depersonalization, which includes feeling detached from one's body. Simeon offered "...common descriptions of depersonalisation experiences: watching oneself from a distance. However, dissociation is remarkably administered by salvinorin A's potent κ-opioid receptor agonism, though sometimes described as an atypical psychedelic; some dissociatives can have CNS depressant effects, thereby carrying similar risks as opioids, which can slow breathing or heart rate to levels resulting in death (w
2C-B-FLY is a psychedelic phenethylamine of the 2C family. It was first synthesized in 1996 by Aaron P. Monte. 2C-B-FLY is 8-bromo-2,3,6,7-benzo-dihydro-difuran-ethylamine. The full name of the chemical is 2-ethanamine, it has been subject to little formal study, but its appearance as a designer drug has led the DEA to release analytical results for 2C-B-FLY and several related compounds. In theory, dihydrodifuran analogues of any of the 2Cx / DOx family of drugs could be made, would be expected to show similar activity to the parent compound. So in the same way that 2C-B-FLY is the dihydrodifuran analogue of 2C-B, the 8-iodo equivalent 2C-I-FLY would be the dihydrodifuran analogue of 2C-I, the 8-methyl equivalent 2C-D-FLY would be the dihydrodifuran analogue of 2C-D. Other related compounds can be produced, where the alpha carbon of the ethylamine chain is methylated, the amphetamine derivative DOB-FLY can be made, this compound being the dihydrodifuran analogue of DOB, or conversely can be viewed as the saturated derivative of Bromo-DragonFLY.
Where only one methoxy group of a 2Cx drug is cyclised into a dihydrofuran ring, the resulting compound is known as a "hemifly", when an unsaturated furan ring is used, the compound is known as a "hemi-dragonfly". The larger saturated hexahydrobenzodipyran ring derivatives have been referred to as "butterfly" compounds; the 8-bromo group can be replaced by other groups to give compounds such as TFMFly. A large number of symmetrical and unsymmetrical derivatives can be produced by using different combinations of ring systems; because the 2- and 5- positions are not equivalent, all unsymmetrical combinations have two possible positional isomers, with different potencies at the various 5-HT2 subtypes. Isomeric "Ψ"-derivatives with the oxygens positioned at the 2,6- positions, mescaline analogues with the oxygens at 3,5- have been made, but both are less potent than the corresponding 2,5- isomers; the symmetrical aromatic benzodifuran derivatives tend to have the highest binding affinity at 5-HT2A, but the saturated benzodifuran derivatives have higher efficacy, while the saturated benzodipyran derivatives are more selective for 5-HT2C.
A large number of possible combinations have been synthesised and tested for activity, but these represent only a fraction of the many variations that could be produced. Alexander Shulgin lists a dosage of 2C-B-FLY at 10 mg orally; the toxicity of 2C-B-FLY in humans is unknown. Two deaths occurred in October 2009, in Denmark and the United States, after ingestion of a substance, sold as 2C-B-FLY a small-time RC shop, but in fact consisted of Bromo-DragonFLY contaminated with a small amount of unidentified impurities; as of October 31, 2016. Http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analog Act if it is intended for human consumption given its similarity to 2C-B; the hallucinogenic effect of 2C-B-FLY is mediated by its partial agonistic activity at the 5-HT2A serotonin receptor, but has a high binding affinity for the 5-HT1D, 5-HT1E, 5-HT1A, 5-HT2B and 5-HT2C receptors.
2C-B-FLY Entry at Erowid 2C-B-FLY Entry at Isomerdesign
AL-LAD known as 6-allyl-6-nor-LSD, is a psychedelic drug and an analog of lysergic acid diethylamide. It is described by Alexander Shulgin in the book TiHKAL, it is synthesized using allyl bromide as a reactant. While AL-LAD has subtly different effects than LSD, appears to be shorter lasting, their potencies are similar. AL-LAD has a known but short and uncommon history of recreational human use, which originated in Ireland and the UK, but spread internationally. AL-LAD does not cause a color change with the Marquis, Mecke or Mandelin reagents, but does cause the Ehrlich's reagent to turn purple because of the presence of the indole moiety in its structure. AL-LAD is not scheduled by the United Nations' Convention on Psychotropic Substances. AL-LAD is illegal in Denmark. AL-LAD is illegal in Latvia. Although it isn't scheduled, it may be controlled as an LSD structural analog due to an amendment made on June 1, 2015. Romania AL-LAD is illegal in Romania, it is not included directly in the list of controlled substances, but it is included in an analogue act The Riksdag added AL-LAD to Narcotic Drugs Punishments Act under swedish schedule I as of January 26, 2016, published by Medical Products Agency in regulation HSLF-FS 2015:35 listed as 6-allyl-6-nor-LSD, AL-LAD, 6-allyl-N,N-dietyl-9,10-didehydroergolin-8-karboxamid.
AL-LAD is illegal in Switzerland. AL-LAD is illegal in the UK. On June 10, 2014 the UK Advisory Council on the Misuse of Drugs recommended that AL-LAD be named in the UK Misuse of Drugs Act as a class A drug despite not identifying any harm associated with its use; the UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 Order 2014. AL-LAD is not scheduled as a controlled substance at the federal level in the United States, but AL-LAD could be considered an analog of LSD, in which case, sales or possession with intent for human consumption could be prosecuted under the Federal Analogue Act. 1P-LSD ETH-LAD PRO-LAD LSZ Watts, V. J.. E.. "LSD and structural analogs: Pharmacological evaluation at D1 dopamine receptors". Psychopharmacology. 118: 401–9. Doi:10.1007/BF02245940. PMID 7568626. Niwaguchi, T. "Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds".
Yakugaku Zasshi. 96: 673–8. Doi:10.1248/yakushi1947.96.5_673. PMID 987200. Robert C. Pfaff, Xuemei Huang, Danuta Marona-Lewicka, Robert Oberlender and David E. Nichols: Lysergamides Revisited. In: NIDA Research Monograph 146: Hallucinogens: An Update. P. 52, 1994, United States Department of Health and Human Services. AL-LAD entry in TiHKAL AL-LAD entry in TiHKAL • info AL-LAD Thread at UKChemicalResearch.org
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may be considered ligands which display both agonistic and antagonistic effects—when both a full agonist and partial agonist are present, the partial agonist acts as a competitive antagonist, competing with the full agonist for receptor occupancy and producing a net decrease in the receptor activation observed with the full agonist alone. Clinically, partial agonists can be used to activate receptors to give a desired submaximal response when inadequate amounts of the endogenous ligand are present, or they can reduce the overstimulation of receptors when excess amounts of the endogenous ligand are present; some common drugs that have been classed as partial agonists at particular receptors include buspirone, buprenorphine and norclozapine. Examples of ligands activating peroxisome proliferator-activated receptor gamma as partial agonists are honokiol and falcarindiol.
Delta 9-tetrahydrocannabivarin is a partial agonist at CB2 receptors and this activity might be implicated in ∆9-THCV-mediated anti-inflammatory effects. Competitive antagonist Intrinsic sympathomimetic activity of beta blockers Inverse agonist Mixed agonist/antagonist